Model of Interactions in Biology and Application to Heterogeneous Network in Yeast.
Smidtas S., Yartseva A., Scachter V., Kepes F.
Compte Rendus de l'Accademie des Sciences - Biologies, 2006
A major challenge for bioinformatics and theoretical biology is to build and analyse a unified model of biological
knowledge resulting from high throughput experiment data. Former work analyzed hetero- geneous data (protein-protein
interactions, genetic regulation, metabolism, synexpression) by modelling them by graphs. These models are unable to
represent the qualitative dynamics of the reactions or to model the n-ary interactions. Here, MIB, a bipartite model of
biological networks, is introduced, and its use for topological analysis of the heterogeneous network is presented.
Heterogeneous loops and links between synexpression pattern and underlying molecular mechanisms are proposed
Movie corresponding to Figure 1. Artistic movie view of the MIB model
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